By Morteza Naghavi (auth.), Morteza Naghavi (eds.)
Despite fresh advances within the analysis and therapy of symptomatic atherosclerosis, to be had conventional screening equipment for early detection and therapy of asymptomatic coronary artery ailment are grossly inadequate and fail to spot the vast majority of sufferers ahead of the onset of a life-threatening occasion. In Asymptomatic Atherosclerosis: Pathophysiology, Detection and remedy, Dr. Morteza Naghavi and prime professionals from the Society for center assault Prevention and Eradication (SHAPE) current a brand new paradigm for the screening and first prevention of asymptomatic atherosclerosis.
The textual content makes a speciality of exact, but underutilized, measures of subclinical atherosclerosis, significantly coronary artery calcium scanning and carotid intima-media thickness dimension. The authors introduce a accomplished method of choosing the weak sufferers (asymptomatic contributors prone to a close to destiny adversarial event). extra chapters talk about destiny instructions in the direction of containing the epidemic of atherosclerotic heart problems utilizing leading edge suggestions corresponding to preemptive interventional treatments (bioabsorbable stents) for stabilization of weak atherosclerotic plaques, mass unconditional Polypill remedy for population-based hazard relief, and eventually vaccination options to avoid the advance of atherosclerosis.
Up-to-date and authoritative, Asymptomatic Atherosclerosis: Pathophysiology, Detection, and remedy is a must have for any heart specialist or fundamental care health practitioner who needs to perform glossy preventive cardiology and deal with the expanding variety of asymptomatic atherosclerotic patients.
• Outlines extra actual measures of threat (coronary artery calcium and carotid intima-media thickness) than conventional hazard elements (total ldl cholesterol, cholesterol, HDL cholesterol)
• provides new multipronged thoughts to help within the early detection and remedy of excessive probability asymptomatic patients
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Additional info for Asymptomatic Atherosclerosis: Pathophysiology, Detection and Treatment
This chapter reports the consensus document created among experts on vulnerable plaque, vulnerable blood, and vulnerable myocardium, and provides an outline of the overall risk assessment of the vulnerable patient. Key words: Atherosclerosis; Vulnerable plaque; Vulnerable blood; Vulnerable myocardium; Vulnerable patient; Plaque rupture Key Points • Plaque rupture is the most common type of plaque complication, accounting for »70% of fatal acute myocardial infarctions and/or sudden coronary deaths.
Invest Radiol. 2000;35:460–471. 39. Ruehm SG, Corot C, Vogt P, et al. Magnetic resonance imaging of atherosclerotic plaque with ultrasmall superparamagnetic particles of iron oxide in hyperlipidemic rabbits. Circulation. 2001;103:415–422. 40. Lederman RJ, Raylman RR, Fisher SJ, et al. Detection of atherosclerosis using a novel positron-sensitive probe and 18-fluorodeoxyglucose (FDG). Nucl Med Commun. 2001;22:747–753. 41. Ciavolella M, Tavolaro R, Taurino M, et al. Immunoscintigraphy of atherosclerotic uncomplicated lesions in vivo with a monoclonal antibody against D-dimers of insoluble fibrin.
A noninvasive option is fibrin-targeted CE-MRI [64, 65]. Severe Stenosis On the surface of plaques with severe stenosis, shear stress imposes a significant risk of thrombosis and sudden occlusion. Therefore, a stenotic plaque may be a vulnerable plaque regardless of ischemia. 5). The current standard technique is invasive x-ray angiography . Noninvasive options include multislice CT [67, 68], magnetic resonance angiography with or without a contrast agent, and electron-beam tomography angiography [59, 69–71].