DDT: The Insecticide Dichlorodiphenyltrichloroethane and Its by W. J. Hayes Jr., S. W. Simmons, E. F. Knipling (auth.), Paul

By W. J. Hayes Jr., S. W. Simmons, E. F. Knipling (auth.), Paul Müller, S. W. Simmons (eds.)

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Extra resources for DDT: The Insecticide Dichlorodiphenyltrichloroethane and Its Significance / Das Insektizid Dichlordiphenyltrichloräthan und Seine Bedeutung: Human and Veterinary Medicine

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The intertubular tissue in treated birds was far in excess of that found in the controls, but the tubular development of the treated birds was very much retarded (BURLINGTON and LINDEMAN [94]). 58 6. PHYSIOLOGY Absorption The toxicity of DDT when administered by different routes offers unimpeachable evidence for the absorption of the compound by those routes. The time of onset of typical signs of intoxication gives some idea of the relative rates of absorption. Thus, rats injected intravenously at the rate of 50 mgjkg showed convulsions in 20 minutes, while those receiving DDT orally at the rate of 500 mgjkg showed convulsions only after 2 hours.

They did not observe a total absence of changes in the liver of male rats which had been exposed to Pharmacology and Toxicology of DDT 55 50 ppm or more of DDT for 4 months or more. However, another laboratory which has frequently observed the changes has found them entirely absent in an occasional group of rats with significant exposure (TREON [595]) . ) have been proposed to explain the observed variation in the intensity of the liver changes. The intensity of the changes does not correlate with the Figure 8 Li ver from a male rat fed 1,000 ppm of DDT for 25 days and then 5,000 ppm for 5 days more.

In this instance there is strong evidence that liver disease preceded exposure to the compound. The presence of ascitic fluid and gross liver pathology quite unlike anything found by others in DDT poisoning was reported for one dog by ZEIN-EL-DINE [685]. The increased size and weight of the liver of rats maintained on a high dietary concentration of DDT is discussed below (p. 111). Rats maintained on high dietary concentrations of DDT may also show a 'nutmeg' appearance or a slight yellowish or tan color of the liver (FITZHUGH and NELSON [208]).

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