By H.-W. Schlipköter (auth.), Prof. Dr. Norbert H. Seemayer, Dipl.-Biologe Wolfgang Hadnagy (eds.)
Environmental pollutants increases severe difficulty all over the world approximately results on human health and wellbeing. in line with a up to date assembly, this publication makes a speciality of various facets of environmental hygiene, facing the review of chemical and actual brokers and their relevance to human well-being. to evaluate the toxicity, mutagenicity and carcinogenicity of environmental toxins, quite a few methodological methods, either in vivo and in vitro, as tissue cultures, remoted organs and animal types, have been constructed and are defined intimately. information on human publicity, organic tracking and epidemiological reports also are integrated. difficulties of environmental regulate and laws in addition to attainable provisional steps are discussed.
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Environmental toxins increases severe situation around the world approximately results on human future health. according to a up to date assembly, this booklet specializes in diversified elements of environmental hygiene, facing the review of chemical and actual brokers and their relevance to human wellbeing and fitness. to evaluate the toxicity, mutagenicity and carcinogenicity of environmental pollution, various methodological methods, either in vivo and in vitro, as tissue cultures, remoted organs and animal versions, have been constructed and are defined intimately.
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175, 97-101. Hadnagy and R. Tomingas (1987) The effect of automobile exhaust particulates on cell viability, plating efficiency and cell division of mammalian tissue culture cells, Sci. , 61, 107-115. A. (1983) A chromosomal hypothesis of oncogenesis, Cancer Genet. Cytogenet, 7, 277-285. , W. Hadnagy, R. Manojlovic (1987) Cell- and genotoxic activities of airborne particulates from a highly industrialized region over a period of 11 years (1975-1986), J. Aerosol. , 18, 721-724. J. Department of Toxicology, Agricultural University, De Dreyen 12, 6703 BC Wageningen, The Netherlands.
S;;. --. -. ~. ____' -____. -__~ o 10 frochon number Figure 2: AMMN induction of DNA single strand breaks in FHLC (a) and rat hepatocytes (b). ), or were additionally exposed to NOx (0) or S02 (e). Short term in vivo studies: For this we treat the animals with the pollutants, and measure the diverse parameters in explanted hepatocytes. After incubating them for 1 h with DMSO or the nitrosamines, enzyme determinations were performed in the medium. The most striking difference was found for the measurement of LDH activity in cell suspensions from 502 treated rats.
Since chromosomal aberrations and numerical chromosome alterations as aneuploidy and polyploidy may playa role in carcinogenesis (JO), both chemical mixtures have to be considered as potentially carcinogenlc. Based on data shown here and early reported (11), it is obvious that cytogenetic testing is of considerable value for predictlng carcinogenic risk by environmental pollutants. L. Atkinson, J. C. L. I. F. I. Sci. Health, A17, 321-389. W. (1983) Lufthygienische Probleme der GroBstadt, Arcus, 5, 244-250.