Local Immunotherapy in Allergy (Chemical Immunology, 82) by Udo R. Markert, Peter Elsner

By Udo R. Markert, Peter Elsner

The prevalence of bronchial asthma is expanding around the globe. Beside the well-established symptomatic remedies and subcutaneous immunotherapies, previously referred to as de- or hyposensitization, a brand new kind of therapy, neighborhood immunotherapy, has been built lately. neighborhood immunotherapy, although nonetheless controversially mentioned, grants to be a healing, noninvasive, and simply acceptable therapy for bronchial asthma. This quantity summarizes the most up-tp-date info on neighborhood immuntherapy compiled via across the world popular experts. within the method part, normal points of neighborhood immunotherapy are offered together with its heritage, allergen resorption and biodistribution, mechanisms of oral tolerance and functional reports. the second one part dedicated to efficacy and safeguard offers findings from overseas placebo-controlled reviews on nasal and sublingual immunotherapies with assorted allergens and for various allergic stipulations together with bronchial asthma and eczema.

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Example text

Thus, extensive fragmentation of Par j 1 does not seem to occur sublingually [44]. Plasma radioactivity was shown to reach a peak at about 2 h following allergen administration by either the sublingual or intranasal route. Plasma radioactivity gel filtration at 1 and 2 h showed a quite different profile with respect to native allergen, in that only a small fraction of radioactivity was present in the molecular weight region of the intact molecule, whereas the majority was in the low molecular weight region (small peptides and free iodine).

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